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OBJECTIVE：To investigate the correlat ion betwe en N-methyl-D-aspartate（NMDA）receptor subunit gene GRIN2B polymorphism and Han population with epilepsy in south Fujian. METHODS ：In retrospective study ，167 healthy people who had physical examination in the Affiliated Dongnan Hospital of Xiamen University were selected from Jan. 2017 to May 2018 as control group；163 epileptic patients who were monitored the blood concentration of sodium valproate were selected as epilepsy group. The clinical data and peripheral blood of 2 groups were collected. 12 loci of GRIN2B genotype（rs11055514，rs11055515，rs12814951， rs74816802，rs2160517，rs2193149，rs966664，rs1805476，rs1806201，rs1805522，rs3764030，rs1019385） in subjects were genotyped. Haploview 4.2 software was used to perform linkage disequilibrium （LD）analysis，and Pearson correlation was used to analyze haplotype. Distribution differences of wild homozygote （AA），mutant heterozygote （Aa）and mutant homozygote （aa） genotypes at 12 loci of GRIN2B gene between 2 groups were analyzed statistically by using GENO ，TREND，DOM and REC. Logistic regression model was used to analyze the correlation of epilepsy induction among 12 loci of GRIN2B gene. RESULTS ： Totally 12 loci of GRIN2B gene were all in line with Hardy-Weinberg equilibrium in 2 groups（P＞0.05）. There was an obvious LD phenomenon between the block 1 composed of rs 11055514，rs11055515，rs12814951，rs74816802，rs2160517，rs2193149 and rs966664 and the block 2 composed of rs 3764030 and rs 1019385（D’＞0.9，r2＞1/3）. There was a correlation between CGGACAG monoploid in block 1 and the occurrence of epilepsy （P＜0.05）. There was statistical significance in the distribution difference of rs74816802 and rs 2193149 between 2 groups（P＜0.05）. The mutation of rs 2193149 locus may cause epilepsy （addition and effect of alleles ：OR＝1.529，L95＝1.017，P＝0.041）. CONCLUSIONS ：The mutation of GRIN2B gene rs 2193149 locus may be one of the risk factors of epilepsy in Han population from south Fujian.
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Objective To observe the clinical efficacy of thunder-fire moxibustion at Dazhui (GV14) and Shenshu (BL23) in treating mild cognitive impairment (MCI) due to ischemic cerebral stroke. Method Sixty patients with MCI due to ischemic cerebral stroke were randomized into a treatment group and a control group, 30 cases each. The control group was intervened by joint treatment plus cognitive training, while the treatment group was by thunder-fire moxibustion in addition to that given to the control group. The two groups were evaluated by the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE) and Wechsler Memory Scale (WMS), the major symptoms were observed, and the clinical efficacies were compared between the two groups. The two groups were both treated for 8 weeks. Result The total effective rate was 80.0%in the treatment group, versus 70.0% in the control group, and the difference was statistically significant(P<0.05). Conclusion The selected acupoints can improve the cognition and activities of daily living (ADL) in MCI patients;thunder-fire moxibustion at Dazhui and Shenshu plus cognitive training can produce a better clinical efficacy than dry cognitive training. Therefore, we can combine thunder-fire moxibustion with modern rehabilitation to enhance the therapeutic efficacy in preventing and treating MCI.
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Objective To investigate the clinical efficacy of Nazi method of midnight-midday ebb flow plus warm needling moxibustion in treating transient ischemic attack (TIA). Methods Sixty patients with transient ischemic attack were randomly allocated to treatment and control groups, 30 cases each. The control group received routine medication and the treatment group, Nazi method of midnight-midday ebb flow plus warm needling moxibustion in addition. The main clinical symptoms were observed by TCD monitoring of microembolic signals in the two groups before and after treatment. The clinical therapeutic effects were compared between the two groups. Results After treatment, the positive rate of microembolus monitoring was 3.3%in the treatment group and 20.0%in the control group;there was a statistically significant difference between the two groups (P<0.05). There was a statistically significant pre-/post-treatment difference in the traditional Chinese medical syndrome score in the two groups (P<0.05). There was a statistically significant post-treatment difference in the traditional Chinese medical syndrome score between the treatment and control groups (P<0.05). The total efficacy rate was 96.7% in the treatment group and 80.0% in the control group;there was a statistically significant difference between the two groups (P<0.05). At six months after treatment, the rate of disappearance of TIA, the rate of recurrence of TIA and the rate of occurrence of cerebral infarction were 90.0%, 6.7%and 3.3%, respectively, in the treatment group and 60.0%, 20.0%and 20.0%, respectively, in the control group;there were statistically significant differences between the two groups (P<0.05). Conclusions Nazi method of midnight-midday ebb flow plus warm needling moxibustion can decrease the positive rate of microemboli and shorten transient ischemic attack to prevent cerebral infarction in patients with transient ischemic attack.
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Objective To compare the effectiveness and safety of different intracranial stents assisted coil embolization of intracranial aneurysms and to discuss the selection of different stent assisted embolization of intracranial aneurysm.Methods From 2007 April to 2012 April,118 cases (a total of 128 wide-neck aneurysms) with intracranial aneurysms were analyzed retrospectively.This included the use of 70 neuroform,38 Enterprise,and 20 Solitaire AB stents forthe treatment of intracranial aneurysms.The successful use,aneurysm occlusion at the immediate post-operation,and early period of peri-operative complications were recorded from those clinical data in order to assess the effectiveness and safety of the different intracranial stents,which assisted coil embolization of intracranial aneurysms.Rank sum test and x2 test were used for statistics.Results Three aneurysms assisted with Neuroform stent were planted unsuccessfully,and the Enterprise and Solitaire stents were placed successfully.The embolism results of three stents after immediate postoperative angiography aneurysm: Neuroform stent occlusion rate was 40.0％ (28/ 70),the tumor residual rate was 38.6 ％ (27/70),and the partial embolization rate was 21.4 ％ (15/70) ; The Enterprise stent occlusion rate was 42.1％ (16/38),the tumor residual rate was 36.8 ％ (14/38),and the partial embolization rate was 21.1％ (8/38).The Solitaire AB stent occlusion rate was 40.0 ％ (8/20),the tumor residual rate was 35.0 ％ (7/20),and the partial embolization rate was 25.0 ％ (5/20).There were not significant differences in aneurismal occlusion (H =0.12,P ＞ 0.05).Early peri-operative complications results were: Neuroform stent occurred in 7,Enterprise frame in 4,and Solitaire AB stent occurred in 2.There were no significant differences in the incidence of complications in the early period after coiling (x2 =0,P ＞ 0.05).Conclusions Three kinds of intracranial stents assisted embolization of intracranial aneurysms are applied safely and effectively.The stent may be chosen according to morphology of parent artery and stent biological character.